We are applying medicinal chemistry (Chemical CryoBiology) approaches to improve the storage of cell based therapies. In the latest work, they apply ROCK (Rho-associated protein kinases) inhibitors to target pathways which lead to cell death after thawing cryopreserved t-cells. This approach is exciting as there is no change required to the cryoprotectants nor the handing process, but just an extra component in the thawing medium, giving up to 20 % more cells: in the context of a cell-based therapy this would be a large increase.
Read the paper here
Post-thaw application of ROCK-inhibitors increases cryopreserved T-cell yield
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